Oxycodone
Buy Oxycodone 30mg online USA.For the naturally occurring peptide hormone, see Oxytocin.
Clinical data | |
---|---|
Pronunciation | ɒksɪˈkəʊdəʊn |
Trade names | OxyContin, Endone, others |
Other names | Eukodal, eucodal; dihydrohydroxycodeinone, 7,8-dihydro-14-hydroxycodeinone, 6-deoxy-7,8-dihydro-14-hydroxy-3-O-methyl-6-oxomorphine[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682132 |
License data | US DailyMed: Oxycodone |
Pregnancy category | AU: C[2] |
Dependence liability | High[3] |
Routes of administration | By mouth, sublingual, intramuscular, intravenous, intranasal, subcutaneous, transdermal, rectal, epidural[4] |
ATC code | N02AA05 (WHO) N02AA55 (WHO) N02AJ18 (WHO) N02AJ19 (WHO) N02AA56 (WHO) N02AJ17 (WHO) |
Legal status | |
Legal status | AU: S8 (Controlled drug) DE: Anlage III (Special prescription form required) UK: Class A US: Schedule II |
Pharmacokinetic data | |
Bioavailability | By mouth: 60–87%[5][6] |
Protein binding | 45%[5] |
Metabolism | Liver: mainly CYP3A, and, to a much lesser extent, CYP2D6 (~5%);[5] 95% metabolized (i.e., 5% excreted unchanged)[8] |
Metabolites | • Noroxycodone (25%) [7][8] • Noroxymorphone (15%, free and conjugated)[7][8] • Oxymorphone (11%, conjugated)[7][8] • Others (e.g., minor metabolites)[8] |
Onset of action | IR: 10–30 minutes[6][8] CR: 1 hour[9] |
Elimination half-life | By mouth (IR): 2–3 hrs (same t1/2 for all ROAs)[8][6] By mouth (CR): 4.5 hrs[10] |
Duration of action | By mouth (IR): 3–6 hrs[8] By mouth (CR): 10–12 hrs[11] |
Excretion | Urine (83%)[5] |
Identifiers | |
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IUPAC name | |
CAS Number | 76-42-6 |
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PubChem CID | 5284603 |
IUPHAR/BPS | 7093 |
DrugBank | DB00497 |
ChemSpider | 4447649 |
UNII | CD35PMG570 |
KEGG | D05312 as HCl: D00847 |
ChEBI | CHEBI:7852 |
ChEMBL | ChEMBL656 |
CompTox Dashboard (EPA) | DTXSID5023407 |
ECHA InfoCard | 100.000.874 |
Chemical and physical data | |
Formula | C18H21NO4 |
Molar mass | 315.369 g·mol−1 |
3D model (JSmol) | Interactive image |
Melting point | 219 °C (426 °F) |
Solubility in water | 166 (HCl) |
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Oxycodone (sold under the brand names Roxicodone and OxyContin, which is the extended release form, among others) is an opioid medication used for treatment of moderate to severe pain. It is highly addictive[12] and is commonly used recreationally by people who have an opioid use disorder.[13][14] It is usually taken by mouth, and is available in immediate-release and controlled-release formulations.[13] Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation.[13] In the United Kingdom, it is available by injection.[15] Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin.[13]Buy Oxycodone 30mg online USA
Common side effects include euphoria, constipation, nausea, vomiting, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating.[13] Severe side effects may include addiction, dependence, aggression, mania or depression, hallucinations, hypoventilation, gastroparesis, bradycardia, and hypotension.[13] Those allergic to codeine may also be allergic to oxycodone.[13] Use of oxycodone in early pregnancy appears relatively safe.[13] Opioid withdrawal may occur if rapidly stopped.[13] Oxycodone acts by activating the μ-opioid receptor.[16] When taken by mouth, it has roughly 1.5 times the effect of the equivalent amount of morphine.[17]
Oxycodone was first made in Germany in 1916 from Thebaine.[18] It is on the World Health Organization’s List of Essential Medicines.[19] It is available as a generic medication.[13] In 2019, it was the 49th most commonly prescribed medication in the United States, with more than 14 million prescriptions.[20][21] A number of abuse-deterrent formulations are available, such as in combination with naloxone or naltrexone.[14][22]
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