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Testosterone is use as a medication for the treatment of male hypogonadism, gender dysphoria, and certain types of breast cancer.^[14][55] This is known as hormone replacement therapy (HRT) or testosterone replacement therapy (TRT), which maintains serum testosterone levels in the normal range. Decline of testosterone production with age has interest in androgen replacement therapy.^[56] It is unclear if the use of testosterone for low levels due to aging is beneficial or harmful.^[57]

Testosterone includes in the World Health Organization’s list of essential medicines, which are the most important medications need in a basic health system.^[58] It is available as a generic medication.^[14] It can be administer as a cream or transdermal patch that  applies to the skin, by injection into a muscle, as a tablet that is place in the cheek, or by ingestion.^[14]